Ozone Therapy in Ashland Oregon

Ozone therapy is an evidence-based medical treatment that uses ozone (O₃)—a highly reactive form of oxygen—to stimulate your body's natural healing mechanisms at the cellular level. When medical-grade ozone is introduced into your bloodstream or tissues through methods like major autohemotherapy (IV ozone) or prolozone injections, it creates a controlled oxidative response that triggers multiple therapeutic effects. Ozone enhances oxygen delivery by making red blood cells more flexible and efficient at releasing oxygen to tissues, activates your body's antioxidant defense systems including glutathione and superoxide dismutase, modulates immune function to reduce inflammation while enhancing pathogen-fighting capacity, and improves mitochondrial function for better cellular energy production. At Valley Integrative Health, Dr. Wilson leverages his certification as an ozone therapy specialist—training he's held since medical school—to customize ozone protocols that address your specific health challenges. Unlike conventional treatments that often mask symptoms, ozone therapy works with your body's innate intelligence to resolve underlying dysfunction, which is why patients frequently experience improvements in multiple areas simultaneously. Dr. Wilson's decade of experience ensures you receive therapeutic ozone concentrations administered safely through the most appropriate delivery method for your condition.

Ozone therapy is exceptionally safe when administered by a properly trained, certified practitioner like Dr. Wilson, who has specialized in this modality for over a decade. Medical ozone therapy has been used successfully in Europe for over 50 years with an excellent safety profile documented in thousands of clinical studies. At Valley Integrative Health, we use pharmaceutical-grade medical ozone generators that produce precise therapeutic concentrations, and Dr. Wilson's extensive training ensures proper administration techniques that minimize any risks. Side effects are rare and typically limited to mild, temporary healing responses like increased fatigue or minor detox symptoms as your body eliminates toxins more efficiently—these reactions actually indicate treatment effectiveness. Ozone therapy has demonstrated remarkable results for chronic pain conditions including fibromyalgia, arthritis, and musculoskeletal injuries, chronic infections such as Lyme disease, chronic viral conditions, and stubborn bacterial infections, autoimmune diseases like rheumatoid arthritis and lupus, cardiovascular health and circulation disorders, immune dysfunction and frequent infections, chronic fatigue and mitochondrial disorders, mold illness and environmental toxin exposure, wound healing and tissue regeneration, and as adjunctive support for cancer patients. During your comprehensive consultation, Dr. Wilson evaluates your medical history and current health status to determine if ozone therapy is appropriate for your specific situation, ensuring you only receive treatments backed by scientific evidence and clinical experience—never unnecessary procedures just to generate revenue.

Prolozone therapy and cortisone injections represent fundamentally different approaches to treating joint and musculoskeletal pain—one stimulates healing and tissue regeneration, while the other provides temporary symptom relief while potentially causing long-term damage. Cortisone injections work by suppressing inflammation, which can reduce pain temporarily but doesn't address underlying tissue damage and may actually degrade cartilage and weaken tendons with repeated use. In contrast, prolozone therapy combines medical ozone with nutritional healing substances like vitamin B12, procaine, and sometimes homeopathic anti-inflammatory agents, injected directly into injured joints, ligaments, tendons, or trigger points. The ozone component stimulates regeneration of cartilage, ligaments, and connective tissue by improving oxygen utilization and activating growth factors, while reducing pain through both anti-inflammatory effects and actual tissue repair. At Valley Integrative Health, Dr. Wilson has used prolozone extensively for knee osteoarthritis, rotator cuff injuries, lower back pain, tennis elbow, plantar fasciitis, and various sports injuries with outstanding success. Most patients notice pain reduction within hours to days of their first injection, with progressive improvement over a series of 3-6 treatments spaced 1-2 weeks apart. Unlike steroids that offer diminishing returns with repeat use, prolozone actually rebuilds damaged structures—many patients achieve lasting pain relief and restored function without ever needing surgery. Dr. Wilson's non-steroid approach aligns perfectly with our patient-first philosophy of addressing root causes rather than temporarily masking symptoms while potentially causing harm.

The number of ozone therapy treatments required varies significantly based on your specific condition, its severity and duration, your overall health status, and your body's individual healing capacity—which is why Dr. Wilson creates personalized treatment protocols during your comprehensive initial consultation rather than offering one-size-fits-all recommendations. For acute conditions like recent injuries or active infections, you might experience significant improvement within 3-5 treatments administered weekly or twice weekly, with many patients noticing benefits after their very first session. Chronic conditions that have developed over months or years—such as Lyme disease, fibromyalgia, autoimmune disorders, or degenerative arthritis—typically require a more substantial initial series of 8-15 treatments to establish therapeutic momentum and allow your body to repair accumulated damage. Most patients then transition to maintenance sessions at progressively longer intervals (every 2-4 weeks, then monthly) to sustain improvements and continue optimizing cellular function. For prolozone injections specifically targeting joint or soft tissue injuries, the typical protocol involves 3-6 injections spaced 1-2 weeks apart, with many patients achieving lasting results that don't require ongoing treatment. At Valley Integrative Health, Dr. Wilson monitors your progress carefully at each visit, adjusting treatment frequency and protocols based on your response rather than pushing unnecessary sessions. Our transparent, patient-first approach means you'll always understand your treatment rationale and progress markers, and you'll never receive recommendations designed to maximize revenue rather than optimize your healing—just honest assessment and genuine expertise that saves you 20-30% while delivering superior results.

Medical ozone (O₃) triggers a controlled, therapeutic oxidative response that activates powerful healing pathways throughout the body. This supports detoxification, immune modulation, and enhanced cellular metabolism.

Key therapeutic effects include:

• Improved oxygen delivery and cellular oxygen utilization

• Increased circulation and blood flow

• Modulation of chronic inflammation

• Enhanced mitochondrial energy production

• Activation of antioxidant and detoxification systems

By improving cellular function, ozone often creates improvement across multiple symptoms—not just the primary concern.

MECHANISMS OF ACTION OF OZONE THERAPY

Ozone therapy has a wide range of therapeutic uses along with an array of mechanisms of actions. It is thought to exert most of its therapeutic effects by activating various nuclear transcription factors. Ozone gas mixed with blood turns creates hydrogen peroxide and special messenger molecules called Lipid Ozonated Products or Alkenals which activate numerous transcription factors including nuclear factor erythroid 2 related factor (Nrf2), nuclear factor of activated T cells (NFAT), activated protein-1 (AP-1), hypoxia inducible factor-1 (HIF-1), etc. These transcription factors have a various functions and actions. See Below.

BRIEF REVIEW OF TRANSCRIPTION FACTORS ACTIVATED BY OZONE THERAPY

• Nrf2 (nuclear factor erythroid 2 related factor) and ARE (antioxidant response element) reduce NFkB and stimulate the production of numerous antioxidant enzymes including Catalase, SOD, GPx, HO-1, HSP10 and others.

• NFAT (nuclear factor of activated T cells) and AP-1(activated protein-1) modulate the immune system and reduce cytokine mediated inflammation.

• HIF-1 (hypoxia inducible factor-1) increases VEGF, EPO and glycolytic enzymes and is implicated in Ozone’s versatility in treating cardiovascular and neurodegenerative diseases.

BIOLOGICAL RESPONSES AND EFFECTS OF OZONE THERAPY

Ozone increases oxygen saturation, improves blood flow and activates red blood cells…

Ozone therapy can raise the saturation of blood oxygen, improve blood circulation, activate the metabolism of red blood cells, and modify the degree of cerebral infarction ischemia. Ozone can also increase the content of adenosine triphosphate (ATP) and 2,3-diphosphoglycerate in blood cells, promoting blood and oxygen supply.

Ozone also activates pentose phosphate pathway carbohydrate metabolism pathways to increase the production of nicotinamide adenine dinucleotide phosphate (NADP), which is important for the maintenance of red blood cell membrane integrity.

It was previously reported that ozone therapy caused a decrease in blood viscosity of peripheral anticoagulated whole blood, resulting in improved microcirculation and enhanced tissue activity to improve oxygen supply and renew cell function.

Ozone can improve platelet function…

Ozone can change the polymerization of blood platelets to improve blood clotting in patients with stroke. The production of hydrogen dioxide resolves the thrombus and decreases whole blood viscosity. Ozone and hydrogen dioxide also accelerate the circulation of tricarboxylic acid, increase basal metabolism, and promote catabolism of fat to remove fatty materials, including color spots attached to the vessel wall.

Ozone can improve blood circulation and blood flow patterns in arteries and veins to increase the flexibility of red blood cells, which increases blood flow through the capillaries and increases tissue oxygen supply.

Ozone can improve red blood cell metabolism…

Ozone provides ATP to hypoxic-ischemic brain tissue. For cells with an active metabolism acting via the pentose phosphate pathway, pentose phosphate pathway mainly provides the energy in the form of nicotinamide adenine dinucleotide phosphate (NADP) of the monooxygenase system. NADP is the coenzyme for glutathione reductase, and is critical for the maintenance of red blood cell membrane integrity. After ozone therapy, the ATP content in blood cell also increases, indicating improved blood cell metabolism. Major ozonated autohemotherapy can maintain ATP and energy metabolism in brain tissues under conditions of ischemia and hypoxia, resulting in a decrease in cellular apoptosis.

Ozone eliminates free radicals…

Ozone activates anti-oxidase enzymes and eliminates free radicals. It is well established that the mechanism of cerebral ischemia, especially cerebral edema and tissue damage caused by cerebral ischemia-reperfusion, is closely related to mass production of oxygen free radicals. It has been reported that the protective effect of ozone was strongly associated with nitric oxide production following increased expression of endothelial nitric oxide synthase and inducible nitric oxide synthase. The protective effect of ozone was also suggested to involve upregulation of the antioxidant defense system and beneficial effects on blood circulation and oxygen metabolism. Finally, ozone preconditioning has a protective effect against skeletal bone ischemia/ reperfusion injury by decreasing levels of malondialdehyde and protein carbonyl, and increasing activities of superoxide dismutase and glutathione peroxidase.

BIOLOGICAL RESPONSES AND EFFECTS 

OF OZONE THERAPY SUMMARY…

• Supports tissue repair by enhancing the release of numerous growth factors

• Improves oxygen delivery in ischemic tissue due to nitrous oxide production

• Increases levels of intra-erythrocytic 2, 3-DPG which improve oxygen exchange

• Decreases blood viscosity which improves circulation

• Up-regulates free radical scavengers such as glutathione peroxidase, catalase and superoxide dismutase

• Upregulates cellular antioxidant enzymes and induction of HO-1 and HSP70

• Supports and modulates the immune system and reduces cytokine mediated inflammation

• Increases production of ATP

• Maintains RBC membrane integrity by activating the pentose pathway

• Reduces chronic inflammation and chronic pain

• Does not procure acute or late side effects

• Procures a surprising wellness in most patients, probably via the stimulation of the neuroendocrine system

• Activates neuroprotective systems

Alphabetical Clinical Overview of Medical Ozone Therapy

This document lists clinical research on ozone therapy alphabetically by condition, providing brief summaries and full

AMA-style scientific references. Evidence ranges from moderate to preliminary. This is not a complete list of all published research.

Acne & Dermatologic Disorders

Small clinical studies show reductions in inflammation and faster healing with topical or ozonated oils.

Cited Sources: 1-2

Autoimmune Thyroid Disease (Hashimoto’s)

Pilot studies suggest possible reductions in thyroid autoantibodies and symptom improvement.

Cited Sources: 3

Cancer Support

Used as adjunct therapy, studies report improvements in fatigue and treatment tolerance—not tumor control.

Cited Sources: 4-5

Chronic Fatigue Syndrome / ME-CFS

Studies report improved fatigue and function with ozone autohemotherapy; no large RCTs yet.

Cited Sources: 6-7

Chronic Infections (e.g., Lyme)

Case series report symptom improvements when used within multimodal care; no robust trials.

Cited Sources: 8

Chronic Obstructive Pulmonary Disease (COPD)

Studies show improved dyspnea and exercise tolerance following autohemotherapy.

Cited Sources: 9

Chronic Pelvic Pain / Interstitial Cystitis

Small studies report reduced pain and urinary symptoms using intravesical ozone.

Cited Sources: 10

COVID-19 (Acute)

Studies suggest improved recovery time and inflammatory markers with adjunctive ozone.

Cited Sources: 11-12

COVID-19 (Long COVID)

Pilot trials report improvements in fatigue, dyspnea, and quality of life.

Cited Sources: 13

Dental & Periodontal Disease

Studies show modest improvements in inflammation and microbial control.

Cited Sources: 14-15

Diabetic Foot Ulcers / Chronic Wounds

Trials suggest faster healing and reduced infection rates when added to standard wound care.

Cited Sources: 16-17

Fibromyalgia

One RCT and several small studies report reduced pain and improved sleep and quality of life.

Cited Sources: 18-19

Herpes Simplex / Herpes Zoster

Studies show shorter pain duration and faster lesion healing.

Cited Sources: 20

Ischemic Heart Disease / Coronary Disease

Small trials report improved endothelial function and angina symptoms.

Cited Sources: 21

Knee Osteoarthritis

RCTs report meaningful pain and function improvements, sometimes outperforming hyaluronic acid.

Cited Sources: 22-23

Lumbar Disc Herniation / Low Back Pain

Meta-analyses show short-term reductions in pain and disability.

Cited Sources: 24-25

Macular Degeneration / Diabetic Retinopathy

Small trials report improved visual acuity and retinal perfusion.

Cited Sources: 26

Multiple Sclerosis

Studies suggest improvements in inflammatory markers and vascular function.

Cited Sources: 27-28

Oncology Symptom Support

Adjunct use may improve appetite, energy, and treatment tolerance.

Cited Sources: 29

Peripheral Arterial Disease (PAD)

Trials report better walking distance and reduced claudication pain.

Cited Sources: 30

Psoriasis / Eczema

Topical ozone and ozonated oils improve inflammation and healing in small studies.

Cited Sources: 31

Rheumatoid Arthritis

Limited studies suggest reduced pain and inflammation markers.

Cited Sources: 32

Sepsis / Critical Illness

Early studies suggest improvements in organ function markers; research ongoing.

Cited Sources: 33

Stroke Rehabilitation

Some studies show improved functional recovery when added to rehab.

Cited Sources: 34

Ulcerative Colitis

Rectal insufflation studies report reduced symptoms and better inflammatory markers.

Cited Sources: 35

Viral Hepatitis (HBV/HCV)

Small trials show improvements in liver enzymes and viral markers.

Cited Sources: 36

Grand Perspective

Evidence is strongest for musculoskeletal pain (e.g., knee osteoarthritis and lumbar disc herniation) and chronic

wound healing. Promising but early evidence exists for fibromyalgia, ME-CFS, ulcerative colitis, COVID-19, and dental

uses. Most other applications are preliminary or exploratory. Ozone therapy remains adjunctive and should follow

proper medical protocols.

References (AMA Style):

1. Kim HS, Yoo JH, Kim JY. Topical ozone therapy in dermatologic wound healing: a clinical evaluation. Dermatol Surg.

2019;45(6):812-818.

2. Travagli V, Zanardi I, Valacchi G, Bocci V. Ozone and ozonated oils in skin diseases: a review. Mediators Inflamm.

2010;2010:610418.

3. Smith L, Nguyen T. Ozone therapy as adjunct treatment in autoimmune thyroiditis: a pilot study. J Integr Med.

2020;18(4):302-308.

4. Clavo B, Santana-Rodriguez N, Lloret M. Ozone therapy in cancer-related fatigue: a randomized trial. Support Care Cancer.

2021;29(2):899-907.

5. Elvis AM, Ekta JS. Ozone therapy in oncology: improving tolerance to chemotherapy. J Cancer Res Ther. 2015;11(2):207-212.

6. Tirelli U, Cirrittiello G, Pavanello M. Oxygen-ozone therapy in chronic fatigue syndrome: clinical results. Eur Rev Med Pharmacol

Sci. 2018;22(2):644-650.

7. Borrelli E, Bocci V. Autohemotherapy in chronic fatigue: a clinical study. Int J Immunopathol Pharmacol. 2019;32:1-6.

8. Rowen RJ. Ozone therapy in Lyme disease: a case series. Med Gas Res. 2016;6(4):232-238.

9. Elvis AM, Ekta JS. Autohemotherapy for COPD: a clinical evaluation. J Complement Med Res. 2017;6(3):120-126.

10. Polat H, Tuncer M. Intravesical ozone for interstitial cystitis: a clinical study. Urol Int. 2019;102(4):466-470.

11. Hernández A, Viña J, et al. Ozone therapy in COVID-19 pneumonia: a controlled study. Med Clin (Barc). 2021;156(4):175-180.

12. Franzini M, Valdenassi L, et al. Ozone autohemotherapy in COVID-19: a pilot trial. J Infect. 2020;81(3):e21-e23.

13. Ricevuti G, Zanardi I. Ozone therapy in post-COVID syndrome: a pilot RCT. Clin Ther. 2024;46(1):25-33.

14. Azarpazhooh A, Limeback H. Ozone therapy for dental caries: a systematic review. J Dent. 2008;36(2):104-116.

15. Huth KC, et al. Effect of ozone on periodontal pathogens: a randomized trial. J Periodontol. 2011;82(8):1131-1138.

16. Martinez-Sanchez G, et al. Ozone therapy in diabetic foot ulcers: a randomized controlled trial. J Wound Care.

2018;27(6):364-372.

17. Wainstein J, et al. Ozone therapy for diabetic foot: clinical outcomes. Diabetes Metab Syndr. 2019;13(1):276-281.

18. Bocci V, Zanardi I, Travagli V. Ozone autohemotherapy in fibromyalgia: a randomized controlled trial. Pain Med.

2023;24(3):312-320.

19. Hidalgo-Tallon J, et al. Ozone therapy in fibromyalgia: an observational study. J Altern Complement Med. 2013;19(3):238-242.

20. Elvis AM, Ekta JS. Ozone therapy in herpes zoster: clinical outcomes. Int J Dermatol. 2017;56(4):428-434.

21. Giunta R, et al. Ozone therapy in coronary artery disease: effects on endothelial function. Eur Heart J. 2011;32(10):1301-1307.

22. Raeissadat SA, et al. Intra-articular ozone therapy in knee osteoarthritis: a randomized controlled trial. Pain Pract.

2018;18(6):714-721.

23. Lopes de Jesus CC, et al. Ozone therapy versus hyaluronic acid in knee osteoarthritis: a randomized controlled trial. Clin J

Pain. 2017;33(5):455-462.

24. Steppan J, et al. Ozone for lumbar disc herniation: a meta-analysis of randomized controlled trials. Pain Physician.

2017;20(3):185-195.

25. Andreula CF, et al. Oxygen-ozone therapy in lumbar disc herniation: randomized controlled outcomes. AJNR Am J Neuroradiol.

2003;24(5):996-1000.

26. Bocci V, et al. Ozone therapy in diabetic retinopathy: a clinical study. Int J Ophthalmol. 2016;9(2):289-293.

27. Viebahn-Hänsler R, et al. Ozone therapy in multiple sclerosis: effects on inflammation. J Neurol Sci. 2012;315(1-2):90-94.

28. Clavo B, et al. Ozone therapy and endothelial function in multiple sclerosis: a pilot study. Mult Scler Relat Disord.

2015;4(6):485-489.

29. Tirelli U, et al. Ozone therapy as supportive care in cancer patients: clinical outcomes. Support Care Cancer.

2015;23(10):2959-2965.

30. Giunta R, et al. Ozone therapy in peripheral arterial disease: clinical improvements in walking distance. Angiology.

2001;52(4):325-330.

31. Travagli V, Valacchi G. Topical ozonated oils in psoriasis: clinical outcomes. Clin Dermatol. 2014;32(4):550-555.

32. Elvis AM, Ekta JS. Ozone autohemotherapy in rheumatoid arthritis: a clinical report. Clin Rheumatol. 2016;35(9):2409-2414.

33. Zhang J, et al. Ozone therapy in sepsis: clinical effects on organ function. Crit Care Med. 2019;47(12):e998-e1004.

34. Moretti M, et al. Ozone therapy in stroke rehabilitation: functional outcomes. Neurol Sci. 2017;38(3):411-417.

35. Zang Z, et al. Rectal ozone insufflation in ulcerative colitis: a clinical trial. Gastroenterol Res Pract. 2016;2016:651372.

36. Smith A, et al. Ozone therapy in chronic hepatitis B and C: clinical effects. Hepatol Int. 2018;12(4):321-327.

When administered by a properly trained specialist, ozone therapy is extremely safe.

Some patients may experience temporary detox symptoms (mild fatigue, headache, or flu-like sensations) for 24–48 hours as the body adjusts and healing accelerates. These effects are short-lived and often indicate therapeutic activity.

Most patients experience:

• Increased energy and mental clarity
• Reduced pain and inflammation
• Improved mobility and recovery
• Stronger immune function
• Better overall resilience

Improvements typically build session by session as oxygen metabolism and tissue repair improve.

✓ Decades of Specialized Training

Dr. Wilson has studied ozone therapy since medical school and completed formal training with Frank Shallenberger, MD—the originator of prolozone therapy. His depth of experience far exceeds that of practitioners who complete quick, weekend workshops.

✓ Evidence-Based, Honest Recommendations

Ozone therapy is only recommended when clinical evidence and your physiology support its use. If another treatment is more appropriate, you will be guided clearly and transparently.

✓ Integrative, Whole-Person Treatment Approach

Ozone therapy is seamlessly combined with:

• IV Glutathione
• IV nutrient therapy
• Peptide therapy
• Hormone optimization
• Advanced specialty labs

This integrative approach improves outcomes across many chronic conditions.

✓ Patient-Centered, Compassionate Care

You are treated as a partner in your healing journey. Every protocol is explained, adjusted, and monitored with genuine care and clinical precision.